Syk InhibitorII is a potent, high selective and ATP-competitiveSykinhibitor with anIC₅₀of 41 nM.Syk InhibitorII inhibits5-HTrelease from RBL-cells with anIC₅₀of 460 nM.Syk InhibitorII shows less potent against other kinases and has anti-allergic effect^[1].

Syk Inhibitor II (compound 9a) shows less potent against PKCε, PKCβ2, ZAP-70, Btk, and Itk with IC₅₀values of 5.1 μM, 11 μM, 11.2 μM, 15.5 μM, and 22.6 μM, respectively^[1].

Syk Inhibitor II (Compound 9a; 10-100 mg/kg) is subcutaneously administered to mice 30 min before antigen challenge. Syk Inhibitor II inhibits the anaphylaxis reaction dose-dependently with an ID₅₀value of 13.2 mg/kg^[1].

340.30

Solid

C₁₄H₁₅F₃N₆O

726695-51-8

Room temperature in continental US; may vary elsewhere.

DMSO : 5 mg/mL(14.69 mM;Need ultrasonic)

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