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Lefitolimod
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:1548439-51-5
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
MGN 1703
产品介绍
Lefitolimod (MGN 1703) 是一种基于 DNA 的TLR9激动剂和免疫监测再激活剂。Lefitolimod 诱发HIV特异性免疫反应,可用于癌症和 HIV-1 的研究。
生物活性

Lefitolimod (MGN 1703) is a DNA-basedTLR9agonist and an immune surveillance reactivator. Lefitolimod induces HIV-specific immune responses and can be used for the research ofcancerandHIV-1[1][4].

IC50& Target[1][4]

TLR9

 

HIV-1

 

体外研究
(In Vitro)

Lefitolimod (MGN 1703) might foster innate and adaptive immune response and thus improve immune-mediated control of residual cancer disease[1].
Lefitolimod targets TLR9-positive pDCs and triggers their secretion of IFN-α to activate the effector cells of innate immunity subsequently leading to an elevated systemic level of IP-10, a chemotactic and angiostatic protein[2].
Lefitolimod (MGN1703) (1 μM; 48 h) stimulates cytokine secretion (interferon (IFN)-α, IFN-γ, interleukin (IL)-12, IL-6, and IL-2) and activates immune cells by increased expression of CD80, CD40, human leukocyte antigen (HLA)-DR and ICAM-1[3].

体内研究
(In Vivo)

Lefitolimod (MGN1703) (2.5 and 60 μg/day; i.p.; daily for 7 days) raises IL-12p40 levels in mice sera without toxicity[3].

Animal Model:Female C57BL6 mice[3]
Dosage:2.5 and 60 μg/day
Administration:Intraperitoneal injection, once daily for 7 days
Result:Were able to raise IL-12p40 levels in mice sera.
CAS 号

1548439-51-5

Sequence

DNA, cyclo[d(A-A-A-A-C-G-T-T-C-T-T-C-G-G-G-G-C-G-T-T-C-T-T-A-G-G-T-G-G-T-A-A-C-C-C-C-T-A-G-G-G-G-T-T-A-C-C-A-C-C-T-T-C-A-T-T-G-G-A-A-A-A-C-G-T-T-C-T-T-C-G-G-G-G-C-G-T-T-C-T-T-A-G-G-T-G-G-T-A-A-C-C-C-C-T-A-G-G-G-G-T-T-A-C-C-A-C-C-T-T-C-A-T-T-G-G)]

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.