ODN 2088 是一种有效的TLR3，TLR7和TLR9抑制剂。ODN 2088 没有细胞毒性。ODN 2088 抑制 IFN-α 和 IL-6 的释放。
| 生物活性 | ODN 2088 is a potentTLR3,TLR7andTLR9inhibitor. ODN 2088 shows no cytotoxic. ODN 2088 inhibits the release of IFN-α andIL-6[1][2][3]. |
体外研究
(In Vitro) | ODN 2088 (0.01, 0.1, 1, 10 μM; 48 h) shows no cytotoxic for for human PBMCs[1].
ODN 2088 (0.01, 0.1, 1, 10 μM; 24 h) inhibits the release of IFN-α in CpG-ODN 2216 (3 μM) and TLR7-ligand RNA-ORN 22075 (5 μM) stimulated human PBMCs[1].
ODN 2088 (0.01, 0.1, 1, 10 μM; 48 h) hardly inhibits the IL-6 release stimulated with CpG-ODN 2006 (100 nM) but inhibits the IL-6 release stimulated with imiquimod (5 μg/ml) in human PBMCs[1].
ODN 2088 (0.1, 1, 10 μM; 24 h) hardly inhibits IL-6 release by B-cells stimulated with CpG-DNA 2006 (100 nM) but inhibits the IL-6 release by imiquimod (5 μg/ml) stimulated human B-cells[1].
ODN 2088 (1, 10 μM; 48 h) increases the expression of CD86 and HLA-DR in the absence of CpG-ODN 2006 or imiquimod in CD20+B-cells[1].
ODN 2088 presumably impairs TLR9-induced signaling induces by CpG-ODNs by competitive binding to the C-terminal fragment of TLR9[1].
ODN 2088 (0.001, 0.01, 0.1, 1, 10 μM; 24 h) inhibits the TNF-α secretion in a dose-dependent manner in CpG-ODN 1826 (100 nM) stimulated BMDMs and shows weekly inhibits when stimulated by the TLR7-agonist imiquimod[3].
ODN 2088 (10 μM) stimulates B cells to proliferate[3].
Cell Cytotoxicity Assay[1] | Cell Line: | Human PBMCs | | Concentration: | 0.01, 0.1, 1, 10 μM | | Incubation Time: | 48 h | | Result: | Showed no cytotoxic for for human PBMCs. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | -20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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