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Dxd-D5
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dxd-D5图片
包装与价格:
包装价格(元)
10 mM * 1 mL in DMSO电议
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品名称
Exatecan-d5 derivative for ADC
产品介绍
Dxd-d5 (Exatecan-d5 derivative for ADC) 是 Dxd 的氘代物。Dxd 是一种有效的 DNA topoisomerase I 抑制剂,IC50值为 0.31 μM,可用作靶作用于 HER2 的抗体偶联药物 ADC (DS-8201a) 的有效载荷。
生物活性

Dxd-d5 (Exatecan-d5 derivative for ADC) is a deuterium labeled Dxd. Dxd is a potent DNAtopoisomeraseI inhibitor, with an IC50of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a)[1].

IC50& Target

Topoisomerase I

0.31 μM (IC50)

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[2].

分子量

498.51

性状

Solid

Formula

C26H19D5FN3O6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

DMSO : 100 mg/mL(200.60 mM;ultrasonic and warming and heat to 60℃)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.0060 mL10.0299 mL20.0598 mL
5 mM0.4012 mL2.0060 mL4.0120 mL
10 mM0.2006 mL1.0030 mL2.0060 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。