您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > ATP-13C10,15N5 disodium
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
ATP-13C10,15N5 disodium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ATP-13C10,15N5 disodium图片
包装:1mg (100 mM in 5mM Tris HCl / H2O)
市场价:7200元

产品名称
Adenosine 5'-triphosphate-13C10,15N5 disodium
产品介绍
ATP-13C10,15N5 (Adenosine 5'-triphosphate-13C10,15N5) disodium 是一种 13C 和 15N 标记的 ATP (HY-B2176). ATP 是体内能量储存和代谢的重要物质,为代谢提供能量,同时在细胞中作为辅酶发挥作用。ATP 是免疫和炎症中重要的内源性信号分子。
生物活性

ATP-13C10,15N5 (Adenosine 5'-triphosphate-13C10,15N5) disodium is a 13C-labeled and 15N-labeledATP(HY-B2176). ATP is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation[1][2][3][4].

体外研究
(In Vitro)

ATP-13C10,15N5 (Adenosine 5'-triphosphate-13C10,15N5; 5 mM; 1 hour) disodium co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs[3].
ATP-13C10,15N5 (2 mM; 0.5-24 hours) disodium induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner[4].
ATP-13C10,15N5 disodium promotes neutrophil chemotaxis in vitro[4].

体内研究
(In Vivo)

ATP-13C10,15N5 (Adenosine 5'-triphosphate-13C10,15N5; 50 mg/kg; i.p.) disodium protects mice against bacterial infection in vivo[4].
ATP-13C10,15N5 disodium induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo[4].

Animal Model:Four-week-old Kunming mice (18-22 g)[4]
Dosage:50 mg/kg
Administration:Intraperitoneal injection, before bacterial (E. coli) challenge
Result:Protected mice from bacterial infection.
分子量

568.05

性状

Liquid

Formula

13C10H1615N5Na2O13P3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Solution, -20°C, 2 years