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17-phenyl trinor Prostaglandin F2α amide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
17-phenyl trinor Prostaglandin F2α amide图片
CAS NO:155205-89-3
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
17-苯基三去甲前列腺素F2α; amide 是比马前列素的 N-去乙基代谢物。
Cas No.155205-89-3
别名比马酰胺
Canonical SMILESO[C@@H]1[C@H](C/C=C\CCCC(N)=O)[C@@H](/C=C/[C@@H](O)CCC2=CC=CC=C2)[C@H](O)C1
分子式C23H33NO4
分子量387.5
溶解度DMF: 30 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml,PBS (pH 7.2): 2 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

17-phenyl trinor Prostaglandin F2α amide (17-phenyl trinor PGF2α amide) is an F-series PG analog in which the C-1 carboxyl group has been modified to an unsubstituted amide. PG esters have been shown to have ocular hypotensive activity. PG N-ethyl amides were recently introduced as alternative PG hypotensive prodrugs. Although it has been claimed that PG amides are not converted to the free acids in vivo, studies have shown that bovine and human corneal tissue converts the amides of various PGs to the free acids with a conversion efficiency of about 10-20% relative to the hydrolysis of isopropyl esters. 17-phenyl trinor PGF2α amide would be expected to show the typical intraocular effects of latanoprost, but with the much slower hydrolysis pharmacokinetics of the PG N-amides.