AFMK 是褪黑激素的抗氧化代谢物，可减轻 X 射线对小鼠 DNA、蛋白质和脂质的氧化损伤。 AFMK 是一种较差的清道夫。 AFMK 在生理 pH 下的 pKa 为 8.7。抗氧化能力。 AFMK 通过调节凋亡通路提高吉西他滨在 PANC-1 细胞中的抗肿瘤作用。
| Cas No. | 52450-38-1 |
| 别名 | N-Γ-乙酰基-N-2-甲酰-5-甲氧基犬尿氨酸 |
| Canonical SMILES | O=CNc1ccc(OC)cc1C(=O)CCNC(=O)C |
| 分子式 | C13H16N2O4 |
| 分子量 | 264.3 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 5 mg/ml,PBS (pH 7.2): 1 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Melatonin is a neurotransmitter widely distributed in eukaryotes and is closely linked to circadean rhythms in mammals including humans. AFMK is a melatonin metabolite first identified in rat brain. AFMK has antioxidant and free radical scavenging activities in several experimental models. AFMK may also be measured in plasma as an index of melatonin synthesis and metabolism. |
m.cnreagent.com