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DHBP dibromide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DHBP dibromide图片
CAS NO:6159-05-3
包装:100mg
市场价:450元

产品介绍
DHBP 二溴化物是一种钙释放抑制剂和一种肌肉松弛剂。
Cas No.6159-05-3
别名二溴化-1,1ˊ-二庚基-4,4ˊ-联吡啶鎓,Diheptylviologen dibromide
化学名1,1'-diheptyl-[4,4'-bipyridine]-1,1'-diium bromide
Canonical SMILESCCCCCCC[N+](C=C1)=CC=C1C2=CC=[N+](C=C2)CCCCCCC.[Br-].[Br-]
分子式C24H38Br2N2
分子量514.39
溶解度Soluble to 100 mM in sterile water
储存条件Store at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

DHBP dibromide is an inhibitor for calcium release and a muscle relaxant.

DHBP inhibits the calcium release induced by 2 mM caffeine and 2 μg/mL polylysine with an IC50 value of 5 μg/mL and 4 μg/mL, respectively. DHBP inhibits [3H]-ryanodine binding in a dose-dependent manner with an IC50 of 2.5 μg/mL and 90-100% inhibition at 20-30 μg/mL. Calcium uptake by SR is inhibited in the presence of caffeine and this inhibition is antagonized by concomitant addition of DHBP. Muscle twitches elicited by direct electrical muscle stimulation and contractions induced by either 10 mM caffeine or 1 fLM ryanodine are blocked by pretreatment with DHBP. DHBP blocks the calcium release from SR by direct interaction with the calcium release channel, also known as the ryanodine receptor[1].

References:
[1]. Kang JJ, et al. Effects of bipyridylium compounds on calcium release from triadic vesicles isolated from rabbit skeletal muscle. Br J Pharmacol. 1994 Aug;112(4):1216-22.