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Ibotenic acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ibotenic acid图片
CAS NO:2552-55-8
包装:5mg
市场价:1890元

产品介绍
Ibotenic acid 在 N-甲基-D-天冬氨酸 (NMDA) 和反式-ACPD 或代谢型 quisqualate (Qm) 受体位点均具有激动剂活性。
Cas No.2552-55-8
别名鹅膏氨酸,(RS)-Ibotenic acid; DL-Ibotenic acid
化学名(S)-2-amino-2-(3-oxo-2,3-dihydroisoxazol-5-yl)acetic acid
Canonical SMILESOC([C@H](C(ON1)=CC1=O)N)=O
分子式C5H6N2O4
分子量158.11
溶解度Water: 10mM
储存条件Desiccate at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ibotenic acid has agonist activity at both the N-methyl-D-aspartate (NMDA) and trans-ACPD or metabolotropic quisqualate (Qm) receptor sites.

Ibotenic acid (Ibo) is capable of acting at both NMDA and trans-ACPD receptors in the CNS, although only activation of NMDA receptors is involved in Ibo neurotoxicity. Ibotenic acid is toxic to cortical neurons exposes for 5 min with an EC50=77.3±8 μM (n=5) as measured by release of lactate dehydrogenase to the culture media[1].

References:
[1]. Zinkand WC, et al. Ibotenic acid mediates neurotoxicity and phosphoinositide hydrolysis by independent receptormechanisms. Mol Chem Neuropathol. 1992 Feb-Apr;16(1-2):1-10.