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Tiagabine hydrochloride
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Tiagabine hydrochloride图片
CAS NO:145821-59-6
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
10mg电议

产品介绍
Tiagabine hydrochloride 是一种有效的选择性 GABA 再摄取抑制剂，用作抗惊厥药，在突触体、神经元和神经胶质细胞中摄取 [3H]GABA 的 IC50 分别为 67、446 和 182 nM。
Cas No.145821-59-6
别名盐酸噻加宾; NO050328 hydrochloride; NO328 hydrochloride; TGB hydrochloride
化学名(R)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-en-1-yl)piperidine-3-carboxylic acid hydrochloride
Canonical SMILESCC(C=CS1)=C1/C(C2=C(C=CS2)C)=C/CCN3CCC[C@](C(O)=O)([H])C3.Cl
分子式C20H26ClNO2S2
分子量412.01
溶解度≥ 16.6mg/mL in DMSO
储存条件Store at 2-8°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tiagabine hydrochloride is a potent and selective GABA reuptake inhibitor, used as an anticonvulsant agent, with IC50s of 67, 446 and 182 nM for [3H]GABA uptake in Synaptosomes, Neurons and Glia, respectively[1].

References:
[1]. Braestrup C, et al. (R)-N-[4,4-bis(3-methyl-2-thienyl)but-3-en-1-yl]nipecotic acid binds with high affinity to the brain gamma-aminobutyric acid uptake carrier. J Neurochem. 1990 Feb;54(2):639-47.
[2]. Sheehan, D.V., et al., An open-label study of tiagabine in panic disorder. Psychopharmacol Bull, 2007. 40(3): p. 32-40.
[3]. Henjum, S. and B. Hassel, High-affinity GABA uptake and GABA-metabolizing enzymes in pig forebrain white matter: a quantitative study. Neurochem Int, 2007. 50(2): p. 365-70.