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Hydroxy-PEG4-acid
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Hydroxy-PEG4-acid图片
CAS NO:937188-59-5
包装与价格：
包装价格(元)
100mg电议
250mg电议

产品介绍
Hydroxy-PEG4-acid 是一种不可降解 (non-cleavable) 的含 4 个单元 PEG 的ADC linker，可用于合成抗体偶联药物 (ADC)。Hydroxy-PEG4-acid 还是一种 PROTAC linker，属于 PEG 类，可用于合成 PROTAC 分子。
Cas No.937188-59-5
分子式C11H22O7
分子量266.29
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Hydroxy-PEG4-acid is a non-cleavable 4 unit PEGADC linkerused in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG4-acid is also a PEG-basedPROTAC linkerthat can be used in the synthesis of PROTACs[1].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].