Pregnenolone-d4-1

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Pregnenolone-d4-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

61574-54-7

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
1mg	电议
5mg	电议
10mg	电议
50mg	电议

产品名称

3β-Hydroxy-5-pregnen-20-one-d4-1

产品介绍

Pregnenolone-d4-1 (3β-Hydroxy-5-pregnen-20-one-d4-1) 是一种氘代标记的 Pregnenolone。Pregnenolone (3β-Hydroxy-5-pregnen-20-one) 是一种功能强大的神经甾体，是包括甾体酮在内的各种甾体激素的主要前体。Pregnenolone 是大麻素CB1受体的信号传导特异性抑制剂，抑制由CB1受体介导的四氢大麻酚 (THC) 的作用。Pregnenolone 可以保护大脑免受大麻中毒。Pregnenolone 也是一种TRPM3通道激活剂，也可以弱激活TRPM1通道。

生物活性

Pregnenolone-d4-1 (3β-Hydroxy-5-pregnen-20-one-d4-1) is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor ofcannabinoidCB1receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by theCB1receptors. Pregnenolone can protect the brain from cannabis intoxication^[1]^[2]. Pregnenolone is also aTRPM3 channelactivator, and also can weakly activateTRPM1 channels^[3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

分子量

320.50

性状

Solid

Formula

C₂₁H₂₈D₄O₂

CAS 号

61574-54-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 31.25 mg/mL(97.50 mM;ultrasonic and warming and heat to 60℃)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	3.1201 mL	15.6006 mL	31.2013 mL
5 mM	0.6240 mL	3.1201 mL	6.2402 mL
10 mM	0.3120 mL	1.5601 mL	3.1201 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。