ATP disodium salt

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ATP disodium salt

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

987-65-5

包装与价格：

包装	价格(元)
500mg	电议
1 g	电议
5 g	电议
10 g	电议
50 g	电议

产品名称

三磷酸腺苷二钠
Adenosine 5'-triphosphate disodium salt
Disodium adenosine triphosphate

产品介绍

ATP disodium salt (Adenosine 5'-triphosphate disodium salt) 是体内能量储存和代谢的重要物质，为代谢提供能量，同时在细胞中作为辅酶发挥作用。ATP disodium salt 是免疫和炎症中重要的内源性信号分子。

生物活性

ATP disodium salt (Adenosine 5'-triphosphate disodium salt) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt is an important endogenous signaling molecule in immunity and inflammation^[1]^[2].

IC₅₀& Target

Human Endogenous Metabolite

体外研究
(In Vitro)

ATP disodium salt (5mM; 1 hour) co-treatment with LPS (1 μg/ml) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs^[3].
ATP disodium salt (2 mM; 0.5-24 hours) induces secretion of interleukin 1β, KC and MIP-2 from bone marrow derived macrophages (BMDMs) in vitro in a caspase-1 activation-dependent manner^[4].
ATP disodium salt stimulats cytokine and chemokine secretion and inflammasome activation directly and indirectly induces in vitro neutrophil chemotaxis^[4].

体内研究
(In Vivo)

ATP disodium salt (50 mg/kg; i.p.) protects mice against bacterial infection in vivo^[4].
ATP disodium salt induces the secretion of IL1β, KC and MIP-2 and neutrophils recruitment in vivo^[4].

Animal Model:	Four-week-old Kunming mice (18-22 g)^[4]
Dosage:	50 mg/kg
Administration:	Intraperitoneal injection, before bacterial (E. coli) challenge
Result:	Protected mice from bacterial infection.

Clinical Trial

分子量

551.14

性状

Solid

Formula

C₁₀H₁₄N₅Na₂O₁₃P₃

CAS 号

987-65-5

中文名称

三磷酸腺苷二钠

结构分类

Others

来源

Plants
other families

Widespread

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

H₂O : 100 mg/mL(181.44 mM;Need ultrasonic)

DMSO : 1 mg/mL(1.81 mM;ultrasonic and warming and heat to 80℃)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	1.8144 mL	9.0721 mL	18.1442 mL
5 mM	0.3629 mL	1.8144 mL	3.6288 mL
10 mM	0.1814 mL	0.9072 mL	1.8144 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.
请依序添加每种溶剂： PBS
Solubility: 100 mg/mL (181.44 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在本网站选购。