Chrexanthomycin C

立即咨询

Chrexanthomycin C

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Chrexanthomycin C 是一种具有显著生物活性的海洋天然产物，具有口服活性。Chrexanthomycin C 对 DNA (G4C2)4 G4 具有结合亲和力，K_d值为 2.8 mM。Chrexanthomycin C 可用于肌萎缩侧索硬化症 (ALS) 等神经退行性疾病的研究。

生物活性

Chrexanthomycin C is an orally active marine natural product with remarkable bioactivities. Chrexanthomycin C has binding affinity forDNA (G4C2)⁴G4with aK_dvalue of 2.8 mM. Chrexanthomycin C can be used for the research of neurodegenerative disease such as amyotrophic lateral sclerosis (ALS)^[1].

IC₅₀& Target

Kd: 2.8 mM (DNA (G4C2)⁴G4)^[1]

体外研究
(In Vitro)

Chrexanthomycin C (Compounds cC) (0.1-10 mM) binds DNA (G4C2)⁴G4 with a K_dvalue of 2.8 mM^[1].
Chrexanthomycin C has good permeability, low cytotoxicity, and nonhemolytic activity^[1].
Chrexanthomycin C (1.57 μM) rescues G4C2 EHR-related pathologies in cells^[1].
Chrexanthomycin C selectively binds to DNA and RNA G4C2 G4s^[1].
Chrexanthomycin C (0-100 μM) dramatically reduceS G4C2 EHR-caused cell death, diminish G4C2 RNA foci in (G4C2)29-expressing Neuro2a cells, and significantly eliminate ROS in HT22 cells^[1].

Cell Viability Assay^[1]

Cell Line:	HEK293T cells
Concentration:	0.16, 1.57 and 15.67 μM
Incubation Time:	24 h
Result:	Showed no cytotoxicity up to the concentration of 10 μg/mL.

体内研究
(In Vivo)

Chrexanthomycin C (Compounds cC) (fed; 100 μM) significantly rescues eye degeneration and improve locomotor deficits in (G4C2)29-expressing^[1].

Animal Model:	Drosophila^[1]
Dosage:	100 μM
Administration:	fed
Result:	Rescued G4C2 EHR-Related Pathologies in Drosophila.

分子量

636.51

Formula

C₃₁H₂₄O₁₅

结构分类

Ketones, Aldehydes, Acids

来源

Streptomyces chrestomyceticus

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.