JAK2 JH2 Tracer

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JAK2 JH2 Tracer

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2101955-00-2

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
1mg	电议
5mg	电议
10mg	电议
50mg	电议
100mg	电议
200mg	电议

产品介绍

JAK2 JH2 Tracer (Tracer 5) 是JAK2 JH2结构域的荧光探针，K_d值为 0.2 μM。

生物活性

JAK2JH2 Tracer (Tracer 5) is a fluorescent probe forJAK2JH2domain, with aK_dof value 0.2 μM^[1]^[2].

体外研究
(In Vitro)

JAK2 JH2 Tracer shows a minimum tracer concentration that retains a satisfactory signal-to-noise ratio is found to be 1.5 pM^[1].
JAK2 JH2 Tracer shows a dissociation constants near 0.2 μM^[1].
JAK2 JH2 Tracer shows a high binding affinity with a K_dvalue of 0.2 μM for JAK2 JH2 domain by saturation experiments^[1].

体内研究
(In Vivo)

The possibility that mutations within the JAK2 JH2 domain may be associated with pathology, which is associated with a hyperactive kinase and a hematopoietic malignancy phenotype in flies^[2].
Specific mutation in the JAK2 JH2 domain is associated with several myeloproliferative diseases^[2].

分子量

747.73

性状

Solid

Formula

C₃₈H₂₇F₂N₇O₆S

CAS 号

2101955-00-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 83.3 mg/mL(111.40 mM)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	1.3374 mL	6.6869 mL	13.3738 mL
5 mM	0.2675 mL	1.3374 mL	2.6748 mL
10 mM	0.1337 mL	0.6687 mL	1.3374 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。