Erythromycin lactobionate

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CAS NO:

3847-29-8

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

红霉素乳糖酸盐

产品介绍

Erythromycin lactobionate 是由放线菌产生的大环内酯类抗生素 (antibiotic)，具有广谱抗菌活性。Erythromycin lactobionate 通过结合细菌的 50S 核糖体亚基而起作用，并通过阻断转肽和/或易位反应来抑制 RNA 依赖性蛋白 (RNA-dependent protein synthesis) 的合成，而不会影响核酸的合成。Erythromycin lactobionate 在不同领域的研究中显示出抗肿瘤特性和保护神经的作用。

生物活性

Erythromycin lactobionate is amacrolideantibioticproduced byactinomycete Streptomyceserythreus with a broad spectrum of antimicrobial activity. Erythromycin lactobionate binds tobacterial50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid^[1][2]. Erythromycin lactobionate also exhibits antitumor and neuroprotective effect in different fields of research^[3][4].

IC₅₀& Target

Macrolide

体外研究
(In Vitro)

Erythromycin lactobionate inhibits growth ofP. falciparumwith IC₅₀and IC₉₀values of 58.2 μM and 104.0 μM, respectively^[1].
Erythromycin lactobionate (10 μM, 100 μM; 24 h, 72 h) shows antioxidant and anti-inflammatory effects and suppresses the accumulation of 4-HNE (p<0.01) and 8-OHdG (p<0.01), reduces Iba-1 (p<0.01) and TNF-α (p<0.01) expression significantly^[4].

Cell Viability Assay^[4]

Cell Line:	Embryos primary cortical neuron (from the cerebral cortices of 17-day-old Sprague-Dawley rat)
Concentration:	10, 100 μM
Incubation Time:	24, 72 hours
Result:	Improved the viability of cultured neuronal cells in vitro after 3 hours oxygen-glucose deprivation (OGD).

体内研究
(In Vivo)

Erythromycin lactobionate (gastric intubation; 0.1-50 mg/kg; 30-120 days) decreases tumor growth and prolong the survival time of mice from dose of 5 mg/kg in mice^[3].
Erythromycin lactobionate (gastric intubation; 5 mg/kg) protects mice alive even at 120 days after inoculation, but shortens mean survival time in tumor-bearing mice by 4-5 days with dose of 50 mg/kg^[3].
Erythromycin lactobionate (i.h.; single injection; 50 mg/kg) has a protective effect on the rat model with cerebral ischemia reperfusion-injury^[4].

Animal Model:	Female ddY mice (6 week-old) with EAC cells or CDF mice (6 week-old) with P388 cells^[3]
Dosage:	0.1 mg/kg; 0.5 mg/kg; 10 mg/kg; 30 mg/kg; 50 mg/kg
Administration:	Gastric intubation; 30-120 days
Result:	Decreased tumor growth and prolonged the mean survival time of mice from the dose of 5 mg/kg, however, the 50 mg/kg dosage shortened the MST in tumorbearing mice.

Animal Model:	Male Sprague-Dawley rats (8-week-old, 250-300 g)^[4]
Dosage:	50 mg/kg
Administration:	Subcutaneous single injection
Result:	Reduced infarct volume and edema volume, improved neurological deficit.

Clinical Trial

分子量

1092.22

Formula

C₄₉H₈₉NO₂₅

CAS 号

3847-29-8

中文名称

红霉素乳糖酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.