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Omadacycline tosylate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Omadacycline tosylate图片
CAS NO:1075240-43-5
包装与价格:
包装价格(元)
10 mM * 1 mL in Water电议
5mg电议
10mg电议
50mg电议
100mg电议
200mg电议

产品名称
奥马环素
PTK 0796 tosylate
Amadacycline tosylate
产品介绍
Omadacycline (PTK 0796) tosylate,首创的具有口服活性的氨基甲基环素抗菌剂,是一种四环素类抗生素。Omadacycline tosylate 通过与 30S 核糖体亚基结合来抑制细菌蛋白质的合成。Omadacycline tosylate 对多种细菌表现出活性,包括好氧和厌氧革兰氏阳性细菌和革兰氏阴性细菌,非典型病原体。Omadacycline tosylate 可用于研究急性细菌性皮肤和皮肤结构感染,感染性肺炎和尿路感染。
生物活性

Omadacycline (PTK 0796) tosylate, a first-in-class orally active aminomethylcyclineantibacterial, is a member of thetetracyclineclass ofantibiotics. Omadacycline tosylate acts through the inhibition ofbacterialprotein synthesisby binding to the 30S ribosomal subunit. Omadacycline tosylate possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline tosylate can be used for the research of acutebacterialskin and skin-structure infections, community-acquired pneumonia, and urinary tract infections[1][2][3][4].

IC50& Target

Tetracycline

 

体外研究
(In Vitro)

Omadacycline displays activity against methicillin-resistantStaphylococcus aureus(MRSA), vancomycin-resistantEnterococcus(VRE), beta-hemolytic streptococci, penicillin-resistantStreptococcus pneumonia(PRSP) andHaemophilus influenzae (H. influenzae), with MIC90s of 1.0, 0.25, 0.5, 0.25 and 2.0 μg/mL respectively[2].
Omadacycline is active against strains expressing tetracycline and other antibiotics resistance by ribosomal protection and active tetracycline efflux[2].

体内研究
(In Vivo)

Omadacycline (0.11-18 mg/kg; a single i.v.) exhibits efficacy againstStreptococcus pneumonia,Escherichia coli, andStaphylococcus aureusin mice systemic infection model, with ED50s ranging from 0.30 mg/kg to 3.39 mg/kg[2].

Clinical Trial
分子量

728.85

性状

Solid

Formula

C36H48N4O10S

CAS 号

1075240-43-5

中文名称

奥马环素;奥玛环素甲磺酸盐;甲苯磺酸奥玛环素

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

H2O : 12.5 mg/mL(17.15 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM1.3720 mL6.8601 mL13.7202 mL
5 mM0.2744 mL1.3720 mL2.7440 mL
10 mM0.1372 mL0.6860 mL1.3720 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: PBS

    Solubility: 50 mg/mL (68.60 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在本网站选购。