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Ertapenem
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ertapenem图片
CAS NO:153832-46-3
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
MK-0826
产品介绍
Ertapenem (MK-0826) 是一种广谱的长效 β-内酰胺抗生素。Ertapenem 对多种厌氧菌具有广谱抗菌活性,其MIC值为 0.12 μg/mL。Ertapenem 可用于皮肤、肺、胃、骨盆和泌尿道的细菌感染相关的研究。
生物活性

Ertapenem (MK-0826) is a broad spectrum and long acting β-lactamantibiotic. Ertapenem has a broad-spectrum anti-anaerobic activity against a variety of anaerobes with a modeMICof 0.12 μg/mL. Ertapenem can be used for the research of severe infections caused by bacteria in the skin, lungs, stomach, pelvis, and urinary tract[1][2].

IC50& Target

β-lactam

 

体外研究
(In Vitro)

Ertapenem (0-100 μg/mL approximately, 48 h) is active against 99.1% of all anaerobes with a mode MIC of 0.12 μg/mL and MIC90of 1 μg/mL, and MIC’s ≥8 μg/mL for B.fragilis and B.vulgatus species, respectively[1].

Cell Viability Assay[1]

Cell Line:B. fragilis(ATCC 25285),B. thetaiotaomicron(ATCC 29741), andEubacterium lentum(ATCC 43055)
Concentration:0-100 μg/mL approximately
Incubation Time:48 h
Result:Inhibited 99.1% of all isolate with a mode MIC of 0.12 μg/mL and MIC90of 1 μg/mL, and 98.8% of the isolates were susceptible among the B. fragilis group.
体内研究
(In Vivo)

Ertapenem (Subcutaneous injection, 0-10 mg/kg, 0-120 h after infection,S. aureusthigh tissue infection model) shows >3 log10CFU reduction of organism at 10 mg/kg, and maintains the activity with 3.3 and 4.4 log10CFU eliminated at 2 mg/kg[2].
Ertapenem (Subcutaneous injection, 4h after infection, systemic infection model) is active against all gram-positive organisms, and is also active against gram-negative organisms tested with ED50s of<0.25 mg/kg/dose[2].

Animal Model:S. aureusthigh tissue infection model (DBA/2 mice)[2]
Dosage:0.5,1, 2, 5, 10 mg/kg (given at 2, 6, 10, 24, 48, 72, 96, 120 h)
Administration:Subcutaneous injection (0.5 mL after infection)
Result:Displayed >3 log10CFU reduction of organism compared to non-antibiotic-treated controls at 10 mg/kg.
Maintained the activity with 3.3 and 4.4 log10CFU eliminated at 2 mg/kg.
Animal Model:Systemic infection model (DBA/2 female mice, viral antibody-free CD-1 female mice)[2]
Dosage:0-3 mg/kg approximately
Administration:Subcutaneous injection (0.5 mL, begin immediately and 4 h after infection)
Result:Showed activity against all gram-positive organisms, and also ram-negative organisms tested with ED50s of<0.25 mg/kg/dose.
Animal Model:CD-1 mice, rats[2]
Dosage:10 mg/kg approximately
Administration:Intraperitoneal injection (pharmacokinetic assay)
Result:Exhibited an AUC0-∞ranging from 1.8-21.82 μgohr/mL in tissue in mice following a 10-mg/kg i.p. dose.
Exhibited slow clearance rate with a t1/2βof 3.2 h, Clp of 0.47 mL/min/kg, AUC0-8of 284.15μgohr/mL.
Clinical Trial
分子量

475.51

Formula

C22H25N3O7S

CAS 号

153832-46-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.