CAS NO: | 82009-34-5 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Cilastatin (MK0791) is a reversible, competitiverenal dehydropeptidase Iinhibitor with anIC50of 0.1 μM. Cilastatin inhibits thebacterialmetallob-lactamase enzyme CphAwith anIC50of 178 μM. Cilastatin is an antibacterial adjunct[1][2][3]. | ||||||||||||||||
IC50& Target |
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体外研究 (In Vitro) | Cilastatin (200 μg/mL; 24 hours; RPTECs) treatment protects against Vancomycin-induced proximal tubule apoptosis and increases cell viability, without compromising the antimicrobial effect of Vancomycin[2]. Apoptosis Analysis[2]
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体内研究 (In Vivo) | In a mouse model (female mice, strain CD-1, 20 g) of systemic infection, Imipenem plus Cilastatin can protect mice fromS. aureus,E. coli, andP. aeruginosainfection[3]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 358.45 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C16H26N2O5S | ||||||||||||||||
CAS 号 | 82009-34-5 | ||||||||||||||||
中文名称 | 西司他丁 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(278.98 mM;Need ultrasonic) 1M NaOH : 100 mg/mL(278.98 mM;ultrasonic and adjust pH to 12 with NaOH) H2O : 12.5 mg/mL(34.87 mM;ultrasonic and warming and heat to 60℃) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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