Imipenem monohydrate,噻吩霉素的稳定结晶衍生物,是一种抗生素,对革兰氏阳性和革兰氏阴性的需氧和厌氧细菌具有良好的抗性。Imipenem monohydrate 可被用于碳青霉烯类非易感性感染和铜绿假单胞菌生物膜感染的研究。
生物活性 | Imipenem monohydrate, a stable crystalline derivative of thienamycin, is anantibioticand has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate can be used for the research of carbapenem-nonsusceptible andP. aeruginosabiofilm infections[1][2][3]. |
体内研究 (In Vivo) | Imipenem monohydrate (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single) has the killing effect in time-dependent[3]. Pharmacokinetic Parameters of Imipenem monohydrate in Neutropenic mouse model of biofilm lung infection (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single)[1].
50Drug and dose(mg/kg) | Cmax(mg/liter) | Tmax(min) | AUCtot(mg o min/liter) | Vz/F(ml/kg) | Vss/F (ml/kg) | CL/F(ml/min/kg) | t1/2(min) | MRT(min) | Imipenem | | | | | | | | | 8 | 15 (7.1) | 21 (11) | 1,470 (777) | 648 (330) | 721 (343) | 6.7 (3) | 67 (11) | 108 (12) | 16 | 34 (6) | 28 (18) | 2,857 (559) | 507 (140) | 543 (121) | 5.8 (1) | 60 (9.1) | 94 (10) | 32 | 54 (11) | 18 (6.1) | 4,895 (635) | 516 (75) | 566 (83) | 6.6 (0.8) | 54 (6.5) | 86 (11) | 64 | 69 (37) | 15 (9.5) | 6,037 (2,976) | 547 (274) | 617 (308) | 7.4 (3.6) | 43 (22) | 70 (35) | |
Animal Model: | Neutropenic mouse model of biofilm lung infection[3] | Dosage: | 4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg | Administration: | 4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single | Result: | Showed the killing effect of time-dependent in mice with biofilm bacterial lung infection in vivo. |
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结构分类 | - Antibiotics
- Other Antibiotics
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运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | *该产品在溶液状态不稳定,建议您现用现配,即刻使用。 |
溶解性数据 | In Vitro: H2O : 7.14 mg/mL(22.50 mM;Need ultrasonic) DMSO :< 1 mg/mL(insoluble or slightly soluble) 配制储备液 1 mM | 3.1510 mL | 15.7550 mL | 31.5100 mL | 5 mM | 0.6302 mL | 3.1510 mL | 6.3020 mL | 10 mM | 0.3151 mL | 1.5755 mL | 3.1510 mL |
*请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液;该产品在溶液状态不稳定,建议您现用现配,即刻使用。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百 分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶 1. 请依序添加每种溶剂: PBS Solubility: 10 mg/mL (31.51 mM); Clear solution; Need ultrasonic and warming and heat to 60℃
*以上所有助溶剂都可在本网站选购。 |