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Chitin synthase inhibitor 2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Chitin synthase inhibitor 2图片
CAS NO:2416338-24-2
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Chitin synthase inhibitor 2 是一种几丁质合酶 (chitin synthase) 抑制剂,IC50为 0.09 mM, Ki为 0.12 mM。Chitin synthase inhibitor 2 在体外具有抗菌活性,对 fluconazole 或 polyoxin B 具有协同或加性作用。
生物活性

Chitin synthase inhibitor 2 (compound 2b) is a potent inhibitor ofchitin synthasewith theIC50value of 0.09 mM and the Kivalue of 0.12 mM. Chitin synthase inhibitor 2 has antimicrobial activities in vitro and shows synergistic or additive effects with fluconazole or polyoxin B[1].

IC50& Target

IC50: 0.09 mM; Ki: 0.12 mM[1]

体外研究
(In Vitro)

Chitin synthase inhibitor 2 (compound 2b) (0, 0.032, 0.126, and 0.25 mM) inhibits chitin synthase with inhibition constant Kivalue of 0.12 mM and the inhibition percent (IP) of 78.3% at 0.3 mM[1].
Chitin synthase inhibitor 2 (1-4 μg/mL) has excellent antifungal activity with MIC (minimum inhibitory concentration) values of 2, 4, 1, and 2 μg/mL against C. albicans (ATCC 76615), A. fumigatus (GIMCC 3.19), C. albicans (ATCC 90023), and A. flavus (ATCC 16870), respectively[1].
Chitin synthase inhibitor 2 (128-512 g/mL) has no antibacterial activity against MRSA (N. 315), S. aureus (ATCC 25923), B. subtilis (ATCC 6633), C. coli (JM 109), P. aeruginosa (ATCC 9027), and B. proteus (ATCC 8427)[1].

分子量

349.38

Formula

C20H19N3O3

CAS 号

2416338-24-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.