Chitin synthase inhibitor 2 (compound 2b) is a potent inhibitor ofchitin synthasewith theIC₅₀value of 0.09 mM and the K_ivalue of 0.12 mM. Chitin synthase inhibitor 2 has antimicrobial activities in vitro and shows synergistic or additive effects with fluconazole or polyoxin B^[1].

IC50: 0.09 mM; Ki: 0.12 mM^[1]

Chitin synthase inhibitor 2 (compound 2b) (0, 0.032, 0.126, and 0.25 mM) inhibits chitin synthase with inhibition constant K_ivalue of 0.12 mM and the inhibition percent (IP) of 78.3% at 0.3 mM^[1].
Chitin synthase inhibitor 2 (1-4 μg/mL) has excellent antifungal activity with MIC (minimum inhibitory concentration) values of 2, 4, 1, and 2 μg/mL against C. albicans (ATCC 76615), A. fumigatus (GIMCC 3.19), C. albicans (ATCC 90023), and A. flavus (ATCC 16870), respectively^[1].
Chitin synthase inhibitor 2 (128-512 g/mL) has no antibacterial activity against MRSA (N. 315), S. aureus (ATCC 25923), B. subtilis (ATCC 6633), C. coli (JM 109), P. aeruginosa (ATCC 9027), and B. proteus (ATCC 8427)^[1].

349.38

C₂₀H₁₉N₃O₃

2416338-24-2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.