Imipenem (MK0787)，噻吩霉素的稳定结晶衍生物，是一种抗生素，对革兰氏阳性和革兰氏阴性的需氧和厌氧细菌具有良好的抗性。Imipenem 可被用于碳青霉烯类非易感性感染和铜绿假单胞菌生物膜感染。
| 生物活性 | Imipenem (MK0787), a stable crystalline derivative of thienamycin, is anantibioticand has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem can be used for the research of carbapenem-nonsusceptible andP. aeruginosabiofilm infections[1][2][3]. |
体内研究
(In Vivo) | Imipenem (MK0787) (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single) has the killing effect in time-dependent[3].
Pharmacokinetic Parameters of Imipenem in Neutropenic mouse model of biofilm lung infection (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single)[1].
50| Drug and dose(mg/kg) | Cmax(mg/liter) | Tmax(min) | AUCtot(mg o min/liter) | Vz/F(ml/kg) | Vss/F (ml/kg) | CL/F(ml/min/kg) | t1/2(min) | MRT(min) | | Imipenem | | | | | | | | | | 8 | 15 (7.1) | 21 (11) | 1,470 (777) | 648 (330) | 721 (343) | 6.7 (3) | 67 (11) | 108 (12) | | 16 | 34 (6) | 28 (18) | 2,857 (559) | 507 (140) | 543 (121) | 5.8 (1) | 60 (9.1) | 94 (10) | | 32 | 54 (11) | 18 (6.1) | 4,895 (635) | 516 (75) | 566 (83) | 6.6 (0.8) | 54 (6.5) | 86 (11) | | 64 | 69 (37) | 15 (9.5) | 6,037 (2,976) | 547 (274) | 617 (308) | 7.4 (3.6) | 43 (22) | 70 (35) | |
| Animal Model: | Neutropenic mouse model of biofilm lung infection[3] | | Dosage: | 4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg | | Administration: | 4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single | | Result: | Showed the killing effect of time-dependent in mice with biofilm bacterial lung infection in vivo. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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