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Imipenem
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Imipenem图片
CAS NO:64221-86-9
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
N-Formimidoyl thienamycin
MK0787
产品介绍
Imipenem (MK0787),噻吩霉素的稳定结晶衍生物,是一种抗生素,对革兰氏阳性和革兰氏阴性的需氧和厌氧细菌具有良好的抗性。Imipenem 可被用于碳青霉烯类非易感性感染和铜绿假单胞菌生物膜感染。
生物活性

Imipenem (MK0787), a stable crystalline derivative of thienamycin, is anantibioticand has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem can be used for the research of carbapenem-nonsusceptible andP. aeruginosabiofilm infections[1][2][3].

体内研究
(In Vivo)

Imipenem (MK0787) (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single) has the killing effect in time-dependent[3].
Pharmacokinetic Parameters of Imipenem in Neutropenic mouse model of biofilm lung infection (4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single)[1].

50
Drug and dose(mg/kg)Cmax(mg/liter)Tmax(min)AUCtot(mg o min/liter)Vz/F(ml/kg)Vss/F (ml/kg)CL/F(ml/min/kg)t1/2(min)MRT(min)
Imipenem
815 (7.1)21 (11)1,470 (777)648 (330)721 (343)6.7 (3)67 (11)108 (12)
1634 (6)28 (18)2,857 (559)507 (140)543 (121)5.8 (1)60 (9.1)94 (10)
3254 (11)18 (6.1)4,895 (635)516 (75)566 (83)6.6 (0.8)54 (6.5)86 (11)
6469 (37)15 (9.5)6,037 (2,976)547 (274)617 (308)7.4 (3.6)43 (22)70 (35)

Animal Model:Neutropenic mouse model of biofilm lung infection[3]
Dosage:4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg
Administration:4 mg/kg, 8 mg/kg, 16 mg/kg, 32 mg/kg, 64 mg/kg, IP, single
Result:Showed the killing effect of time-dependent in mice with biofilm bacterial lung infection in vivo.
Clinical Trial
分子量

299.35

Formula

C12H17N3O4S

CAS 号

64221-86-9

中文名称

亚胺培南

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.