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Chloroquine dihydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Chloroquine dihydrochloride图片
CAS NO:3545-67-3
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Chloroquine dihydrochloride 是一种广泛用于疟疾和类风湿性关节炎的抗疟疾和抗炎剂。Chloroquine dihydrochloride 是autophagytoll-like receptors (TLRs)的抑制剂。Chloroquine dihydrochloride 有效抑制SARS-CoV-2 (COVID-19)感染 (EC50=1.13 μM)。
生物活性

Chloroquine dihydrochloride is anantimalarialand anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine dihydrochloride is anautophagyandtoll-like receptors (TLRs)inhibitor. Chloroquine dihydrochloride is highly effective in the control ofSARS-CoV-2 (COVID-19)infectionin vitro (EC50=1.13 μM)[1][2][3][4].

IC50& Target[1][2][3][5]

Plasmodium

 

Malaria

 

TLRs

 

SARS-COV-2

 

HIV-1

 

体外研究
(In Vitro)

Chloroquine dihydrochloride (20 μM) inhibits IL-12p70 release and reduces Th1-priming capacity of activated human monocyte-derived Langerhans-like cells (MoLC). Chloroquine dihydrochloride (20 μM) enhances IL-1–induced IL-23 secretion in MoLC and subsequently increases IL-17A release by primed CD4+ T cells[1]. Chloroquine dihydrochloride (25 μM) suppresses MMP-9 mRNA expression in normoxia and hypoxia in parental MDA-MB-231 cells. Chloroquine dihydrochloride has cell-, dose- and hypoxia-dependent effects on MMP-2, MMP-9 and MMP-13 mRNA expression[2]. TLR7 and TLR9 inhibition using IRS-954 or Chloroquine dihydrochloride significantly reduces HuH7 cell proliferation in vitro[3].
Chloroquine dihydrochloride (0.01-100 μM; 48 hours) potently blocked virus infection (vero E6 cells infected with SARS-CoV-2) at low-micromolar concentration (EC50=1.13 μM). Chloroquine dihydrochloride blocks virus infection by increasing endosomal pH required for virus/cell fusion, as well as interfering with the glycosylation of cellular receptors of SARS-CoV[4].

体内研究
(In Vivo)

Chloroquine dihydrochloride (80 mg/kg, i.p.) does not prevent the growth of the triple-negative MDA-MB-231 cells with high or low TLR9 expression levels in the orthotopic mouse model[2].
TLR7 and TLR9 inhibition using IRS-954 or Chloroquine dihydrochloride significantly inhibits tumour growth in the mouse xenograft model. HCC development in the DEN/NMOR rat model is also significantly inhibited by Chloroquine[3].

Clinical Trial
分子量

392.79

Formula

C18H28Cl3N3

CAS 号

3545-67-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.