Kukoamine B 是枸杞皮的一种成分，具有抗氧化、抗急性炎症和抗糖尿病的特性。
| Cas No. | 164991-67-7 |
| 别名 | 地骨皮乙素 |
| Canonical SMILES | OC1=C(O)C=CC(CCC(N(CCCCNCCCNC(CCC2=CC(O)=C(O)C=C2)=O)CCCN)=O)=C1 |
| 分子式 | C28H42N4O6 |
| 分子量 | 530.7 |
| 溶解度 | DMF: 30 mg/mL,DMSO: 30 mg/mL,Ethanol: 30 mg/mL,PBS (pH 7.2): 10 mg/mL |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Kukoamine B is a spermine alkaloid first isolated from a traditional Chinese herb L. chinense that inhibits both lipopolysaccharides (LPS) and oligodeoxynucleotides containing CpG motifs (CpG DNA). It is reported to inhibit proinflammatory signal transduction and cytokine expression induced by LPS and CpG DNA (Kds = 1.24 and 0.66 µM). LPS and CpG DNA are two well-recognized pathogen-associated molecular patterns (PAMPs) that play a role in triggering sepsis, thus sepsis may be attenuated by simultaneously neutralizing LPS and CpG DNA. |
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