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C16 dihydro Ceramide(d18:0/16:0)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
C16 dihydro Ceramide(d18:0/16:0)图片
CAS NO:5966-29-0
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍

A bioactive sphingolipid

Cas No.5966-29-0
别名Cer(d18:0/16:0) ; Ceramide (d18:0/16:0); N-hexadecanoyl-D-erythro-Dihydrosphingosine; N-Palmitoyl Sphinganine
化学名N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]-hexadecanamide
Canonical SMILESO=C(CCCCCCCCCCCCCCC)N[C@@H](CO)[C@H](O)CCCCCCCCCCCCCCC
分子式C34H69NO3
分子量539.9
溶解度Chloroform:Methanol (5:1): Soluble,DMSO: Soluble,Ethanol: Soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
文献引用
产品描述

C16 dihydro Ceramide is a bioactive sphingolipid and precursor in the de novo synthesis of C16 ceramide (d18:0/16:0) that lacks the 4,5-trans double bond.[1] C16 dihydro Ceramide (0-46 nM) inhibits C16 ceramide-induced membrane permeabilization, measured as cytochrome C oxidation, in rat liver mitochondria in a concentration-dependent manner. It also inhibits C16 ceramide-induced channel formation in liposomes. C16 dihydro ceramide is biologically inactive as a single agent, lacking the ability to induce apoptosis, cytochrome C release, or channel formation in phospholipid membranes in the absence of C16 ceramide.

Reference:
[1]. Stiban, J., Fistere, D., and Colombini, M. Dihydroceramide hinders ceramide channel formation: Implications on apoptosis. Apoptosis 11(5), 773-780 (2006).