Micronomicin sulfate (Gentamicin C2b sulfate) is anaminoglycosideantibioticisolated fromMicromonospora. Micronomicin sulfate is a broad-spectrumantibioticclose to the gentamicin-typeantibiotics, exhibits a high activity againstPseudomonas,Proteus,Klebsiella pneumoniae,Serratia, etc (MIC=0.001-8.3 μg/ml)^[1][2].

Micronomicin has a potent antibacterial activity, it is active againstStaphylococcus aureusFDA 209 P,Staphylococcus aureuswith the minimal inhibitory values of 0.01 μg/ml. It is also againstEscherichia coliSt.M. 589, Baker 2, F 14-BK, and R5/W677 with the minimal inhibitory values of 0.75 μg/ml, 0.3 μg/ml, 0.03 μg/ml and 0.03 μg/ml. And it is active againstPseudomonas aeruginosastrains andlebsiella pneumoniaestrains (MICs = 0.03-17.5 μg/ml)^[1].

Micronomicin sulfate is highly active against various bacterial infections in mice, and has an intravenous acute LD₅₀in mice of 93 mg/kg^[1].
Micronomicin sulfate (intravenous injection; 4-100 mg/kg; 30 days) is injected for subacute toxicity study. The wistar rats dies at the dose level of 100 mg/kg (10 out of 30 animals): renal disorders and ataxia. The renal histological disorders occurrs mainly at the dose levels of 25 mg/kg and over^[3].

Solid

C₂₀H₄₁N₅O₇.xH₂SO₄

66803-19-8

硫酸小诺霉素；沙加霉素

• Antibiotics
• Other Antibiotics

Micromonospora

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

H₂O : 50 mg/mL(Need ultrasonic)

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

• 1.

  请依序添加每种溶剂： PBS

  Solubility: 100 mg/mL (Infinity mM); Clear solution; Need ultrasonic