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Amikacin hydrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Amikacin hydrate图片
CAS NO:1257517-67-1
包装与价格:
包装价格(元)
50mg电议
100mg电议
500mg电议

产品名称
BAY 41-6551 hydrate
产品介绍
Amikacin hydrate (BAY 41-6551 hydrate) 是一种氨基糖苷类抗生素,也是一种卡那霉素的半合成类似物。Amikacin hydrate 具有杀菌作用,直接作用于 30S 和 50S 细菌核糖体亚基,可抑制蛋白质合成。Amikacin hydrate 对大多数革兰氏阴性细菌 (Gram-negative bacteria) (包括庆大霉素和妥布霉素抗性菌株) 非常有效。Amikacin hydrate 还抑制易感诺卡氏菌和非结核分枝杆菌引起的感染。
生物活性

Amikacin hydrate (BAY 41-6551 hydrate) is anaminoglycosideantibiotic and a semisynthetic analog of kanamycin. Amikacin hydrate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin hydrate is very active against mostGram-negative bacteriaincludinggentamicin- andtobramycin-resistant strains. Amikacin hydrate also inhibits the infections caused by susceptibleNocardiaandnontuberculous mycobacteria[1][2].

IC50& Target

Aminoglycoside

 

体外研究
(In Vitro)

Amikacin offers definite advantages for treating infections caused by organisms resistant to other aminoglycosides. Amikaci is affected by relatively few arninoglycoside-modifying enzymes. Amikacin is useful in the treatment of infections caused byNocardia asteroides,Mycobacterium avium-intracellulare, and certain species of "rapid-growing" mycobacteria (that is,M. chelonaeandM. fortuitumi)[1].
Amikacin (100-1500 μM) causes a reliable dose-dependent loss of lateral line zebrafish hair cells with a LD50value of 453 μM[3].

体内研究
(In Vivo)

Amikacin (320 mg/kg; subcutaneous injection; daily; for 10 days; male Fischer rats) treatment increases the chance of serious hearing loss in rats in vivo[3].

Animal Model:Male Fischer 344 rats (40-50-day-old)[3]
Dosage:320 mg/kg
Administration:Subcutaneous injection; daily; for 10 days
Result:Induced hearing loss in rats.
Clinical Trial
分子量

408.51

Formula

C20H28N2O5S

CAS 号

1257517-67-1

中文名称

阿米卡星水合物;丁胺卡那霉素水合物

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据
In Vitro: 

H2O : 100 mg/mL(244.79 mM;Need ultrasonic and warming)

DMSO :< 1 mg/mL(insoluble or slightly soluble)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.4479 mL12.2396 mL24.4792 mL
5 mM0.4896 mL2.4479 mL4.8958 mL
10 mM0.2448 mL1.2240 mL2.4479 mL