Cefuroxime is an orally active second-generation cephalosporinantibioticwith increased stability toβ-lactamase. Cefuroxime has a broad spectrum activity against Gram-positive and Gram-negative bacteria^[1].

Cefuroxime is highly active againstS. aureus(MIC=0.25 μg/ml), regardless of whether the strains produces a penicillinase. It is againstStaphylococcus aureusmethicillin susceptible;S. aureus, methicillin resistant,Streptococcus pyogenes,S. pneumoniae,S. viridans,S. faecalis, andClostridium sppwith MIC values of 0.25 μg/ml, 5.9 μg/ml, 0.125 μg/ml, 0.125 μg/ml, 0.125 μg/ml, >125.0 μg/ml, and 1.2 μg/ml, respectively^[1].
Cefuroxime (10-100 μg/ml; 2-6 hours) rapidly bactericidal, its action is comparatively slow against the strains ofS. aureus, but, even so, over 99% of the initial inoculum is killed by 6 h. The gram-negative organisms are killed rapidly, and in most cases over 99% of the very large inocula are killed within 2 h; the β-lactamase-producing strains are killed as quickly as non-enzyme-producing strains^[1].

Rabbits (weighing 2.0 to 2.5 kg) are challenged intravenously withS. aureusstrain 630 (a penicillinase-producing strain), the median effective dose of Cefuroxime is 3 mg/kg as a result of the protection test^[2].

424.39

C₁₆H₁₆N₄O₈S

55268-75-2

头孢呋辛酯EP杂质D

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.