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Oxytetracycline Dihydrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Oxytetracycline Dihydrate图片
CAS NO:6153-64-6
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
土霉素二水合物
产品介绍
Oxytetracycline dihydrate 是一种属于四环素类的抗生素。Oxytetracycline dihydrate 强力抑制革兰氏阴性和革兰氏阳性细菌。Oxytetracycline dihydrate 是一种蛋白质合成抑制剂,可阻止 aminoacil-tRNA 与复杂的核糖体 RNA 结合。Oxytetracycline dihydrate 还具有抗HSV-1的活性。
生物活性

Oxytetracycline dihydrate is anantibioticbelonging to thetetracyclineclass. Oxytetracycline dihydrate potent inhibitsGram-negative and Gram-positive bacteria. Oxytetracycline dihydrate is aprotein synthesisinhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline dihydrate also possesses anti-HSV-1activity[1][2][3].

IC50& Target[1][3]

Tetracycline

 

HSV-1

 

Bacterial

 

Microbial Metabolite

 

体外研究
(In Vitro)

Oxytetracycline is an important member of the bacterial aromatic polyketide family, which is a structurally diverse class of natural products. Oxytetracycline is synthesized by a type II polyketide synthase that generates the poly-beta-ketone backbone through successive decarboxylative condensation of malonyl-CoA extender units, followed by modifications by cyclases, oxygenases, transferases, and additional tailoring enzymes[2].

体内研究
(In Vivo)

The effects of administration a therapeutic dose of Oxytetracycline (82.8 mg/kg of bw to 1 % bw/day) for 10 days are species specific. Oxytetracycline increases the relative liver weight inMorone chrysops x M. saxatilis, the enzymatic activity of CYP3A4 in Ictalurus punctatus, protein expression of CYP3A4 in Oreochromis niloticus and depleted the hepatic CYP3A4 in the latter[1].
For Oxytetracycline, the limits are 100 μg/kg in muscle and milk, 200 μg/kg in egg, 300 μg/kg in liver and 600 μg/kg in kidney. Oxytetracycline (OTC) is administered to fish as medicated feed at concentrations ranging from 35 to 75 mg a.i kg-1 biomass day-1 for 7-14 days[1].

分子量

496.46

Formula

C22H28N2O11

CAS 号

6153-64-6

中文名称

土霉素二水合物;地霉素二水合物;氧四环素二水合物

结构分类
  • Phenols
  • Monophenols
  • Antibiotics
  • Other Antibiotics
来源

Streptomyces rimosus

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.