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Gatifloxacin mesylate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Gatifloxacin mesylate图片
CAS NO:316819-28-0
包装与价格:
包装价格(元)
500mg电议
1 g电议

产品名称
甲磺酸加替沙星
AM-1155 mesylate
BMS-206584 mesylate
PD135432 mesylate
产品介绍
Gatifloxacin mesylate (AM-1155 mesylate) 是一种有效的氟喹诺酮类抗生素 (antibiotic),具有广谱抗菌活性。Gatifloxacin mesylate (AM-1155 mesylate) 可抑制细菌 II 型拓扑异构酶 (type II topoisomerases) (IC50=13.8 μg/ml; 金黄色葡萄球菌拓扑异构酶 IV) 和大肠杆菌 DNA 解旋酶 (IC50=0.109 μg/ml)。Gatifloxacin mesylate (AM-1155 mesylate) 在动物模型中,可用于细菌性结膜炎研究。
生物活性

Gatifloxacin mesylate (AM-1155; BMS-206584; PD135432) is a potent fluoroquinoloneantibioticwith broad-spectrum antibacterial activity. Gatifloxacin mesylate inhibitsbacterialtype II topoisomerases(IC50=13.8 μg/ml forS. aureustopoisomeraseIV) andE. coliDNA gyrase(IC50= 0.109 μg/ml)[1]. Gatifloxacin mesylate can be used to treatbacterialconjunctivitis in vivo.

IC50& Target[1]

Quinolone

 

Topoisomerase II

36.7 μM (IC50)

体外研究
(In Vitro)

Gatifloxacin mesylate is againstS. aureus MS5935 topoisomerase IV,E. coli NIHJ JC-2 DNA gyrase and HeLa cell topoisomerase II with IC50values of 13.8 μg/ml, 0.109 μg/ml, and 265 μg/ml, respectively[1].
Gatifloxacin mesylate is againstS. aureus MS5935 topoisomerase IV,E. coli NIHJ JC-2 DNA gyrase and HeLa cell topoisomerase II with MIC values of 0.05 μg/ml, 0.0063 μg/ml, and 122 μg/ml, respectively[1].
Gatifloxacin mesylate exhibits antibacterial activities for wild-type strains (MS5935, MS5952, MR5867 and MR6009) the first-, second-, third-, and fourth-step mutants with MIC values of 0.05 to 0.10 μg/ml, 0.20 μg/ml, 1.56 to 3.13 μg/ml, 1.56 to 6.25 μg/ml, and 50 to 200 μg/ml, respectively. Gatifloxacin mesylate displays the most potent activity against the second- and third-step mutants (MS5952, MR5867 and MR6009) except for the second-step mutant of strain MS5935[2].
Gatifloxacin mesylate has potent activity against norA transformant NY12 (MIC, 0.39 μg/ml)[2].
Gatifloxacin mesylate (20-100 μM; 72 hours) significantly decreases insulin content to 60% at Day 1, and continues to be reduced to 50.1% and 44.7% at Day 3 by 20 μM and 100 μM Gatifloxacin mesylate, respectively[3].

体内研究
(In Vivo)

Gatifloxacin mesylate (subcutaneous injection; 100 mg/kg; 3 times a day; 30 days) significantly decreases the number of lesions in mouse footpad withNocardia brasiliensis[4].

Animal Model:Female BALB/c mice withNocardia brasiliensisin the right hind footpad.
Dosage:100 mg/kg
Administration:Subcutaneous injection; 3 times a day; 30 days
Result:Reduced the production of lesions in mice.
Clinical Trial
分子量

471.50

Formula

C20H26FN3O7S

CAS 号

316819-28-0

中文名称

甲磺酸加替沙星

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.