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Azithromycin hydrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Azithromycin hydrate图片
CAS NO:117772-70-0
包装与价格:
包装价格(元)
50mg电议
100mg电议
200mg电议
500mg电议

产品名称
阿奇霉素二水合物
CP-62993 dihydrate
产品介绍
Azithromycin hydrate (CP-62993 dihydrate) 是一种大环内酯抗生素,常用于细菌感染的研究。
生物活性

Azithromycin hydrate is a macrolideantibioticuseful for the treatment of a number ofbacterialinfections.

IC50& Target

Macrolide

 

体外研究
(In Vitro)

Azithromycin (2 μM) augments rhinovirus-induced IFNβ expression in primary bronchial epithelial cells from asthmatics, which is associated with over-expression of RIG-I like receptors and repression of viral replication. Knockdown of MDA5, but not knockdown of RIG-I, diminishes azithromycin (2 μM)-enhanced viral-induced IFNβ expression in asthmatic primary bronchial epithelial cells[1]. Azithromycin specifically reduces MMP-9 mRNA and protein levels without affecting NF-κB in endotoxin-challenged monocytic THP-1 cells[2].

体内研究
(In Vivo)

Azithromycin (50 mg/kg) has no effect on bronchoalveolar lavage inflammatory parameters and LDH levels in a mouse model of asthma exacerbation. Azithromycin induces neither general inflammatory parameters nor LDH release in a mouse model of asthma exacerbation, and augments expression of interferon-stimulated genes and the pattern recognition receptor MDA5 but not RIG-I in exacerbating mice[1].

Clinical Trial
分子量

785.02

Formula

C38H76N2O14

CAS 号

117772-70-0

中文名称

阿奇霉素二水合物

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.