Calcimycin hemimagnesium

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

72124-77-7

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议

产品名称

A-23187 hemimagnesium
Antibiotic A-23187 hemimagnesium

产品介绍

Calcimycin (A-23187) hemimagnesium 是一种抗生素和独特的二价阳离子离子载体 (divalent cation ionophore)，如钙离子和镁离子。Calcimycin hemimagnesium 通过增加细胞内钙浓度诱导 Ca²⁺依赖性细胞死亡。Calcimycin hemimagnesium 抑制革兰氏阳性细菌和一些真菌的生长，还抑制 ATP 酶的活性并解耦哺乳动物细胞的氧化磷酸化 (OXPHOS)，诱导细胞凋亡 (apoptosis)。

生物活性

Calcimycin (A-23187) hemimagnesium is anantibioticand a uniquedivalent cation ionophore(like calcium and magnesium). Calcimycin hemimagnesium induces Ca²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemimagnesium inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemimagnesium also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemimagnesium inducesapoptosis^[1]^[2]^[3]^[4].

体外研究
(In Vitro)

Calcimycin (A-23187) hemimagnesium mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner^[4].

体内研究
(In Vivo)

Calcimycin (A-23187) hemimagnesium (2.5 or 7.5 nM; intrapleurally) induces protein leakage^[5].

Animal Model:	Mice (ICR, 25-30 g)^[5]
Dosage:	2.5 or 7.5 nM
Administration:	Intrapleurally
Result:	Two hours after 2.5 nM, or three hours after 7.5 nM, challenge the protein levels in the pleural cavity were equivalent to about a half of their corresponding peak values.

Clinical Trial

分子量

1069.53

Formula

C₅₈H₇₂MgN₆O₁₂

CAS 号

72124-77-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.