Tenofovir diphosphate (TFV-DP) is a competitiveDNA polymerasesinhibitor (with respect to dATP) and a substrate ofHIVtype 1 (HIV-1)reverse transcriptase(RT)^[1].

DNA polymerases; HIV-1 reverse transcriptase^[1]

Tenofovir diphosphate acts as an inhibitor of DNA pol. Tenofovir-diphosphate is a weak inhibitor of DNA polymerases (pol) α, δ, and e, with values for the K_ifor PMPApp (^PMPAppK_i) relative to the K_mfor dATP (^dATPKm) of 10.2, 10.2, and 15.6, respectively^[1].

447.17

C₉H₁₆N₅O₁₀P₃

166403-66-3

替诺福韦二磷酸酯

Room temperature in continental US; may vary elsewhere.

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