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Tenofovir maleate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tenofovir maleate图片
CAS NO:1236287-04-9
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
替诺福韦马来酸盐
GS 1278 maleate
PMPA maleate
产品介绍
Tenofovir maleate (GS 1278 maleate) 是一种核苷酸逆转录酶 (nucleotide reverse transcriptase) 抑制剂,有潜力用于艾滋病毒和慢性乙型肝炎的研究。
生物活性

Tenofovir Disoproxil Fumarate is anucleotidereverse transcriptase inhibitorto treatHIVand chronic Hepatitis B.

IC50& Target

HIV-1

 

体外研究
(In Vitro)

Tenofovir shows cytotoxic effects on cell viability in HK-2 cells, with IC50values of 9.21 and 2.77 μM at 48 and 72 h in MTT assay, respectively. Tenofovir diminishes ATP levels in HK-2 cells. Tenofovir (3.0 to 28.8 μM) increases oxidative stress and protein carbonylation in HK-2 cells. Furthermore, Tenofovir induces apoptosis in HK-2 cells, and that apoptosis is induced via mitochondrial damage[1]. Tenofovir and M48U1 formulated in 0.25% HEC each inhibits the replication of both R5-tropic HIV-1BaLand X4-tropic HIV-1IIIbin activated PBMCs, and inhibits several laboratory strains and patient-derived HIV-1 isolates. The combined formulation of M48U1 and tenofovir in 0.25% HEC exhibits synergistic antiretroviral activity against infection with R5-tropic HIV-1BaL, and is not toxic to PBMCs[2].

体内研究
(In Vivo)

Tenofovir Disoproxil Fumarate (20, 50, 140, or 300 mg/kg) administered to BLT mice, shows dose dependent activity during vaginal HIV challenge in BLT humanized mice. Tenofovir Disoproxil Fumarate (50, 140, 300 mg/kg) significantly reduces HIV transmission in BLT mice[3]. Tenofovir Disoproxil Fumarate (0.5, 1.5, or 5.0 mg/kg/day, p.o.) induces a dose-dependent decline in serum viremia in woodchucks chronically infected with WHV. Tenofovir Disoproxil Fumarate administration is safe and effective in the woodchuck model of chronic HBV infection[4].

Clinical Trial
分子量

403.28

Formula

C13H18N5O8P

CAS 号

1236287-04-9

中文名称

替诺福韦马来酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.