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Arachidonoyl-L-carnitine(chloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Arachidonoyl-L-carnitine(chloride)图片
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议

产品介绍
别名C20:4 Carnitine
化学名(R)-3-carboxy-2-((5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyloxy)-N,N,N-trimethylpropan-1-aminium, monochloride
Canonical SMILESCCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(O[C@H](CC(O)=O)C[N+](C)(C)C)=O.[Cl-]
分子式C27H46NO4•Cl
分子量484.1
溶解度DMF: 20 mg/ml,DMSO: 10 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml
储存条件Store at -80°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Carnitine facilitates the transport of fatty acids into the mitochondria to be used in fatty acid metabolism. It does so by accepting acyl groups from fatty acids complexed with coenzyme A, which yields esterified carnitine or acylcarnitines that enable the transport of fatty acyl groups into the inner mitochondrial matrix. β-Oxidation of fatty acids in mitochondria is inhibited by uncoupling conditions, thus changes in circulating levels of various acylcarnitines have been used to identify alterations in metabolic state.[1] [2] Arachidonoyl-L-carnitine formed from carnitine conjugated to arachidonic acid .

Reference:
[1]. Osmundsen, H., Cervenka, J., and Bremer, J. A role for 2,4-enoyl-CoA reductase in mitochondrial β-oxidation of polyunsaturated fatty acids. Effects of treatment with clofibrate on oxidation of polyunsaturated acylcarnitines by isolated rat liver mitochondria. Biochemistry Journal 208(3), 749-757 (1982).
[2]. Sampey, B.P., Freemerman, A.J., Zhang, J., et al. Metabolomic profiling reveals mitochondrial-derived lipid biomarkers that drive obesity-associated inflammation. PLoS One 7(6), e38812 (2012).