| CAS NO: | 675576-97-3 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 50mg | 电议 |
| Cas No. | 675576-97-3 |
| 别名 | 4-[[(4R,5S)-4,5-双(4-氯苯基)-4,5-二氢-2-[4-甲氧基-2-(1-甲基乙氧基)苯基]-1H-咪唑-1-基]羰基]-2-哌嗪酮 |
| 化学名 | 4-[(4R,5S)-4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one |
| Canonical SMILES | CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl |
| 分子式 | C30H30Cl2N4O4 |
| 分子量 | 581.49 |
| 溶解度 | DMF: 14 mg/ml,DMSO: 14 mg/ml,Ethanol: 20 mg/ml,Ethanol:PBS (pH7.2) (1:7): 0.12 mg/ml |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Nutlin-3b is an inactive enantiomer of nutlin-3 [1]. Nutlin-3 is a small-molecule inhibitor of MDM2, interfering with MDM2-directedTP53 degradation. The stabilization of WT-TP53 leads to cell cycle arrest, growth inhibition, and apoptosis. As an inactive enantiomer, Nutlin-3b does not show any effect on the proliferation and has no insignificant effect on gene expression in cancer cells. Nutlin-3b binds MDM2 with about 200-fold lower affinity and is 150 times less active than 3a (an active enantiomer of nutlin-3). Nutlin-3b is usually used as a negative control. It shows no induction of MDM2, p53 or p21 expression and has no ability in colony-formation in H460 cell line. It also has no effect on cell cycle [1, 2]. References: |
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