Simeprevir-13C,d3 (TMC435-13C,d3) is the 13C- and deuterium labeled Simeprevir. Simeprevir is an oral, potent and highly specifichepatitis C virus (HCV) NS3/4A proteaseinhibitor with aK_iof 0.36 nM. Simeprevir inhibitsHCVreplication with anEC₅₀of 7.8 nM. Simeprevir also potently suppressesSARS-CoV-2replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (M^pro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses^[1][2][5].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

753.95

C₃₇¹³CH₄₄D₃N₅O₇S₂

西咪匹韦 13Cd3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.