您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Panobinostat lactate
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Panobinostat lactate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Panobinostat lactate图片
CAS NO:960055-56-5
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
LBH589 lactate
NVP-LBH589 lactate
产品介绍
Panobinostat lactate 是一种有效的口服非选择性HDAC抑制剂,具有抗肿瘤活性。Panobinostat lactate 可有效干扰HIV潜伏期。Panobinostat lactate 诱导细胞凋亡 (apoptosis) 和自噬 (autophagy)。Panobinostat lactate 可用于难治性或复发性多发性骨髓瘤的研究。
生物活性

Panobinostat lactate is a potent and orally active non-selectiveHDACinhibitor. Panobinostat lactate has antineoplastic activities. Panobinostat lactate effectively disruptsHIVlatency. Panobinostat lactate induces cellapoptosisandautophagy. Panobinostat lactate can be used for the study of refractory or relapsed multiple myeloma[1][2][3][4][5].

IC50& Target

HDAC

 

HIV-1

 

体外研究
(In Vitro)

Panobinostat lactate induces apoptosis of both MOLT-4 and Reh cells in a time- and dose-dependent manner. Panobinosta lactate results in histone (H3K9 and H4K8) hyperacetylation and regulation of cell-cycle control genes in Reh cells[1].
Panobinostat lactate exhibites potent antiproliferative activity in human NSCLC cell lines with the IC50ranging from 5 to 100 nM[2].

体内研究
(In Vivo)

Panobinosta lactate (10, 20 mg/kg, i.p.) significantly slows tumor growth derived from Meso and NSCLC cells in vivo models. Panobinosta lactate markedly increases acetylation of histone H3 and H4 of H69 human SCLC cells harvest from SCID mice[2].
Panobinostat lactate (5, 10 and 20 mg/kg i.p.) demonstrates a clear benefit of decreased tumor burden, significantly improves TTE and reduces bone density loss in a disseminated multiple myeloma mouse model[3].

Clinical Trial
分子量

439.50

Formula

C24H29N3O5

CAS 号

960055-56-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.