Lopinavir-d8 (ABT-378-d8) is the deuterium labeled Lopinavir. Lopinavir (ABT-378) is a highly potent, selective peptidomimetic inhibitor of theHIV-1protease, withK_isof 1.3 to 3.6 pM for wild-type and mutantHIV protease. Lopinavir acts by arresting maturation ofHIV-1thereby blocking its infectivity^[1][2]. Lopinavir is also aSARS-CoV3CL^proinhibitor with anIC₅₀of 14.2 μM^[3].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

636.85

C₃₇H₄₀D₈N₄O₅

1224729-35-4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.