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NSC228155
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NSC228155图片
CAS NO:113104-25-9
规格:≥98%
包装与价格:
包装价格(元)
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)290.25
FormulaC11H6N4O4S
CAS No.113104-25-9
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 58 mg/mL (199.8 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
SMILES O=[N+](C1=CC=C(SC2=CC=CC=[N+]2[O-])C3=NON=C31)[O-]
Synonyms NSC228155; NSC-228155; NSC 228155
实验参考方法
In Vitro

In vitro activity: NSC 228155 promotes transactivation of several RTKs, including ErbB2 and ErbB3, Insulin R and IGF-1 R receptors in the cells. It stimulates dimerization of sEGFR domain II. NSC 228155 can rapidly move across cell membranes and disperse within both cytoplasmic and nuclear compartments. It rapidly generates hydrogen peroxide within cells. NSC 228155 is also a potent inhibitor of KIX-KID interaction(IC50 = 0.36 μM), but it is not particularly selective against CREB-mediated gene transcription in HEK 293T cells.


Cell Assay: MDA MB468 cells serum-starved overnight are pre-incubated (or not) with 10 μM AG1478 or 2 μM PD 153035 for 90 min and then, where indicated, incubated with 100 μM NSC 228155 or CN 009543V or 150 ng/ml EGF or vehicle (0.2% DMSO) for 15 min. Proteins are blotted to nitrocellulose membrane and analyzed with biotinylated anti-pTyr P100, anti-pEGFR Y1068 and anti-EGFR (epitope in cytoplasmic region) antibodies.

In VivoUp to now, there is no animal in vivo data reported.
Animal model
Formulation & Dosage
ReferencesSci Rep. 2014 Feb 5;4:3977. doi: 10.1038/srep03977; Sci Rep. 2016 Feb 17;6:21088; Bioorg Med Chem Lett. 2013 Oct 1;23(19):5371-5.