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Benznidazol(Ro 07-1051)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Benznidazol(Ro 07-1051)图片
CAS NO:22994-85-0
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
100mg电议

产品介绍
Benznidazol (Ro 07-1051) (Ro 07-1051) 是一种抗寄生虫药物，IC50 为 20.35 μM 代表哥伦比亚 T.
Cas No.22994-85-0
别名苄硝唑; Ro 07-1051; Ro 71051
Canonical SMILESO=C(NCC1=CC=CC=C1)CN2C=CN=C2[N+]([O-])=O
分子式C12H12N4O3
分子量260.25
溶解度DMSO : 160 mg/mL (614.79 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Benznidazol (Ro 07-1051) is an antiparasitic medication, with an IC50 of 20.35 μM for Colombian T. cruzi strains, and has been used in the treatment of Chagas disease[1][2].

Benznidazole (100 mg/kg/day, p.o., 30 days) produces a decrease in electrocardiographic alterations, fewer modifications in the affinity and density of cardiac-receptors, and few isolated areas of fibrosis in the heart, in mice infected with Trypanosoma cruzi Tulahuen strain or SGO-Z12 isolate and treated at 180 days post infection (p.i.) (i.e. chronic phase) with Benznidazole[1].|| Animal Model:|Mice infected with Trypanosoma cruzi Tulahuen strain or SGO-Z12[1]|Dosage:|100 mg/kg/day |Administration:|Orally for 30 days|Result:|Produced a decrease in electrocardiographic alterations, fewer modifications in the affinity and density of cardiac-receptors, and few isolated areas of fibrosis in the heart.

[1]. Bustamante JM, et al. Treatment with benznidazole or thioridazine in the chronic phase of experimental Chagas disease improves cardiopathy. Int J Antimicrob Agents. 2007 Jun;29(6):733-7. [2]. Luna KP, et al. In vitro susceptibility of Trypanosoma cruzi strains from Santander, Colombia, to hexadecylphosphocholine (miltefosine), nifurtimox and benznidazole. Biomedica. 2009 Sep;29(3):448-55.