| CAS NO: | 865363-93-5 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| Cas No. | 865363-93-5 |
| 别名 | 2'-脱氧-4'-C-乙炔基-2-氟腺苷,MK-8591 |
| Canonical SMILES | OC[C@]1(C#C)[C@H](C[C@H](N2C=NC3=C2N=C(F)N=C3N)O1)O |
| 分子式 | C12H12FN5O3 |
| 分子量 | 293.25 |
| 溶解度 | DMSO: 20.83 mg/mL (71.03 mM; ultrasonic and adjust pH to 3 with HCl); Water: 3.57 mg/mL (12.17 mM; ultrasonic and warming and heat to 60℃) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Islatravir (MK-8591) is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively. Islatravir (MK-8591) (4'Ed2FA) is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively[1]. [1]. Ohrui H, et al. 2'-deoxy-4'-C-ethynyl-2-fluoroadenosine, a nucleoside reverse transcriptase inhibitor, is highly potent against all human immunodeficiency viruses type 1 and has low toxicity. Chem Rec. 2006;6(3):133-43. |
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