您好，欢迎来到化工原料网！ [登录] [免费注册]
化工原料网
发布求购
位置：首页 > 产品库 > RO-7
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
RO-7
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
RO-7图片
CAS NO:1370241-45-4
包装与价格：
包装价格(元)
250mg电议
500mg电议

产品介绍
RO-7是甲型和乙型流感病毒的二代聚合酶PA亚基内切核酸酶抑制剂。
Cas No.1370241-45-4
Canonical SMILESO=C1N([C@H](C)C(F)(F)F)CN([C@@H]2C3=CC=CC=C3SCC4=CC=CC=C24)N5C1=C(O)C(C=C5)=O
分子式C24H20F3N3O3S
分子量487.49
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

RO-7 is a next-generation polymerase (PA) endonuclease inhibitor of influenza A and B viruses.

RO-7 is a compound that potently inhibits influenza virus replication and belongs to a new class of drugs in late-stage clinical trials for treatment of influenza virus infection. RO-7 displays broad-spectrum anti-influenza activity in vitro and protects mice from lethal challenge with both influenza A and B viruses[1].

RO-7 protects mice from lethal challenge with both influenza A and B viruses[1].

[1]. Jones JC, et al. Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation InfluenzaVirus Endonuclease Inhibitors. MBio. 2018 Apr 24;9(2). pii: e00430-18.