Sulfaclozine sodium

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Sulfaclozine sodium

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

23307-72-4

包装与价格：

包装	价格(元)
10 mM * 1 mL in Water	电议
100mg	电议
200mg	电议
500mg	电议

产品名称

Sulfachloropyrazine sodium

产品介绍

Sulfaclozine sodium (Sulfachloropyrazine sodium) 是一种有效的磺酰胺衍生物，具有抗菌和抗球虫作用。Sulfaclozine sodium 通常用于各种家禽疾病(尤其是结肠杆菌病，禽霍乱和球虫病)的相关研究。

生物活性

Sulfaclozine sodium (Sulfachloropyrazine sodium) is an efficacious sulphonamide derivative with antibacterial and anticoccidial effects. Sulfaclozine sodium is commonly used for the treatment of various poultry diseases (particularly, collibacteriosis, fowl cholera and coccidiosis)^[1].

IC₅₀& Target

Coccidia

体外研究
(In Vitro)

The elimination of Sulfaclozine in the three systems: UV/TiO₂, UV/K₂S₂O₈, and UV/TiO₂/K₂S₂O₈. Sulfaclozine is weakly adsorbed on the surface of TiO₂at pH 7 (< 5%) but efficiently eliminated with the following three systems: UV/TiO₂, UV/K₂S₂O₈, and UV/TiO₂/K₂S₂O₈in ultra pure water. Moreover, 12 of Sulfaclozine by-products are identified and reaction pathways show that, in addition of^oOH and SO₄^o–radicals, the conduction-band electrons are responsible for the formation of some main by-products either directly or by the formation of superoxide radicals^[2].

体内研究
(In Vivo)

Sulfaclozine (60 mg/kg; intravenous injection or oral administration; male broiler chickens) can be used primarily for the treatment of parasitic and microbial infections of the digestive tract rather than for the treatment of systemic infections^[1].

Animal Model:	14 male broiler chickens (30-day-old)^[1]
Dosage:	60 mg/kg
Administration:	Intravenous injection or oral administration (Pharmacokinetic Analysis)
Result:	Serum drug concentrations at 0.083, 0.50, 2, 6, 24 and 72h were determined to be 99.62, 83.50, 72.68, 58.43, 38.66 and 13.14 μg/mL, respectively, by intravenous injection. By oral administration were determined as 4.33, 7.95, 16.46, 22.88, 16.03 and 5.74 μg/mL, respectively.

分子量

306.70

性状

Solid

Formula

C₁₀H₈ClN₄NaO₂S

CAS 号

23307-72-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

H₂O : 50 mg/mL(163.03 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	3.2605 mL	16.3026 mL	32.6051 mL
5 mM	0.6521 mL	3.2605 mL	6.5210 mL
10 mM	0.3261 mL	1.6303 mL	3.2605 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。