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Sulfaclozine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sulfaclozine图片
CAS NO:102-65-8
包装与价格:
包装价格(元)
100mg电议
200mg电议
500mg电议

产品名称
磺胺氯吡嗪
Sulfachloropyrazine
产品介绍
Sulfaclozine (Sulfachloropyrazine) 是一种有效的磺酰胺衍生物,具有抗菌和抗球虫作用。Sulfaclozine 有潜力用于各种家禽疾病(尤其是结肠杆菌病,禽霍乱和球虫病)。
生物活性

Sulfaclozine (Sulfachloropyrazine) is an efficacious sulphonamide derivative with antibacterial and anticoccidial effects. Sulfaclozine is commonly used for the treatment of various poultry diseases (particularly, collibacteriosis, fowl cholera and coccidiosis)[1].

IC50& Target

Coccidia

 

体外研究
(In Vitro)

The elimination of Sulfaclozine in the three systems: UV/TiO2, UV/K2S2O8, and UV/TiO2/K2S2O8. Sulfaclozine is weakly adsorbed on the surface of TiO2at pH 7 (< 5%) but efficiently eliminated with the following three systems: UV/TiO2, UV/K2S2O8, and UV/TiO2/K2S2O8in ultra pure water. Moreover, 12 of Sulfaclozine by-products are identified and reaction pathways show that, in addition ofoOH and SO4o–radicals, the conduction-band electrons are responsible for the formation of some main by-products either directly or by the formation of superoxide radicals[2].

体内研究
(In Vivo)

Sulfaclozine (60 mg/kg; intravenous injection or oral administration; male broiler chickens) can be used primarily for the treatment of parasitic and microbial infections of the digestive tract rather than for the treatment of systemic infections[1].

Animal Model:14 male broiler chickens (30-day-old)[1]
Dosage:60 mg/kg
Administration:Intravenous injection or oral administration (Pharmacokinetic Analysis)
Result:Serum drug concentrations at 0.083, 0.50, 2, 6, 24 and 72h were determined to be 99.62, 83.50, 72.68, 58.43, 38.66 and 13.14 μg/mL, respectively, by intravenous injection. By oral administration were determined as 4.33, 7.95, 16.46, 22.88, 16.03 and 5.74 μg/mL, respectively.
分子量

284.72

Formula

C10H9ClN4O2S

CAS 号

102-65-8

中文名称

磺胺氯吡嗪

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据
In Vitro: 

DMSO : ≥ 29 mg/mL(101.85 mM)

*"≥" means soluble, but saturation unknown.

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM3.5122 mL17.5611 mL35.1222 mL
5 mM0.7024 mL3.5122 mL7.0244 mL
10 mM0.3512 mL1.7561 mL3.5122 mL
In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40%PEG300   5%Tween-80   45% saline

    Solubility: ≥ 2.5 mg/mL (8.78 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (8.78 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH2O 中,得到澄清透明的生理盐水溶液
  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20%SBE-β-CDin saline)

    Solubility: ≥ 2.5 mg/mL (8.78 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (8.78 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂: 10% DMSO    90%corn oil

    Solubility: ≥ 2.5 mg/mL (8.78 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (8.78 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在本网站选购。