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Bulaquine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bulaquine图片
CAS NO:79781-00-3
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
CDRI 80/53
Elubaquine
产品介绍
Bulaquine (CDRI 80/53) 是有效的抗疟疾剂,是 Primaquine (HY-12651A) 的类似物。Bulaquine 影响多条代谢途径,对Plasmodium cynomolgi感染有抑制作用。Bulaquine 可用于疟疾的研究。
生物活性

Bulaquine (CDRI 80/53) is a potentantimalarial agentwhich is an analogue ofPrimaquine(HY-12651A). Bulaquine affects multiple metabolism pathways and shows inhibition effect onPlasmodiumcynomolgiinfection. Bulaquine can be used for the research of malaria[1][2][3].

IC50& Target

Plasmodium

 

体内研究
(In Vivo)

Bulaquine (40 mg/kg; p.o. once) affects multiple pathways in vivo[1].
Bulaquine (1.25 mg/kg; once daily; for 7 days) shows 100% curative anti-relapse activity with a primaquine index of 0.8 for rhesus monkeys withPlasmodium cynomolgiB infection[2].

Animal Model:25-30 g male Swiss albino mice[1]
Dosage:40 mg/kg
Administration:Oral gavage; 40 mg/kg once
Result:Affected oxidative stress and fatty acid synthesis pathway, apoptosis, cell cycle, inflammatory response, glycogen metabolism, Kreb’s cycle, electron transport chain, fatty acid β-oxidation, MAPK signalling, signalling of hepatocyte growth factor receptor, matrix metalloproteinases, steroid biosynthesis, TGF-β signalling, translation factors, Wnt signalling, regulation of actin cytoskeleton, ribosomal proteins, RNA transcription reactome, proteasome degradation and nuclear receptors in lipid metabolism according to GO results.
分子量

369.46

Formula

C21H27N3O3

CAS 号

79781-00-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.