Antimalarial agent 18

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包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Antimalarial agent 18 是一种有效的抗疟剂，具有电子、亲脂性和铁疏性。Antimalarial agent 18 属于酰氧基甲基系列，可作为磷霉素替代品，磷霉素是针对非甲羟戊酸类异戊二烯生物合成途径的有效 IspC 抑制剂。Antimalarial agent 18 能抑制恶性疟原虫和鲍曼疟原虫生长，IC₅₀分别为 50 nM 和 390 nM。

生物活性

Antimalarial agent 18 is an potent antimalarial agent, based on electronic, highly lipophilic and siderophoric properties. Antimalarial agent 18 belongs to acyloxymethyl series, as a fosmidomycin surrogate, which is potent IspC inhibitor against the non-mevalonate isoprenoid biosynthesis pathway. Antimalarial agent 18 inhibitsP. falciparum(IC₅₀=50 nM) andA. baumanii(IC₅₀=390 nM)^[1].

IC₅₀& Target

Plasmodium

体外研究
(In Vitro)

Antimalarial agent 18 (compound 13j) is the long chain octanoyl analog, shows cytotoxicity against MRC-5 fibroblasts with an IC₅₀value of 40.3 μM^[1].
Antimalarial agent 18 poorly inhibits avirulentM. tuberculosisstrain (H37Ra) with an IC₅₀value >64 μM^[1].
Antimalarial agent 18 may serve as a lead for future analog development of MEP pathway inhibitors against Gram-negative pathogens in general, andA. baumanniiin particular^[1].

分子量

509.57

Formula

C₂₃H₄₄NO₉P

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.