从骨碎补根茎中分离出的 Neoeriocitrin 在 MC3T3-E1 中显示出增殖和成骨分化活性。
| Cas No. | 13241-32-2 |
| 别名 | 新北美圣草苷 |
| Canonical SMILES | O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](OC2=CC(O)=C(C(C[C@@H](C3=CC=C(O)C(O)=C3)O4)=O)C4=C2)[C@@H]1O[C@@]5([H])[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5 |
| 分子式 | C27H32O15 |
| 分子量 | 596.5 |
| 溶解度 | DMF: 15 mg/ml,DMSO: 30 mg/ml,DMSO:PBS(pH 7.2) (1:4): 0.2 mg.ml,Ethanol: 1 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Neoeriocitrin is a flavonoid that has been found in C. paradisi and has antioxidative and osteogenic activities. It inhibits the production of 2,2-diphenyl-1-picrylhydrazyl radicals by 17.2% and the formation of superoxide radicals by 48.3% in cell-free assays, as well as decreases the rate of LDL oxidation ex vivo in isolated hamster plasma. Neoeriocitrin (2 µg/ml) increases proliferation of MC3T3-E1 osteoblast percursor cells and reverses the antiproliferative effect of the MEK1 inhibitor PD 98059 . It also increases the expression of the osteogenic differentiation markers Runx2, Type 1 collagen, and osteocalcin. |
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