Camptothecin-d5 (Campathecin-d5) is the deuterium labeled Camptothecin. Camptothecin (CPT), a kind of alkaloid, is aDNAtopoisomeraseI (Topo I) inhibitorwith anIC₅₀of 679 nM^[1]. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulateshypoxia-inducible factor-1α (HIF-1α)activity by changingmicroRNAs(miRNA)expression patterns in humancancercells^[2][3].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

353.38

C₂₀H₁₁D₅N₂O₄

1329616-37-6

喜树碱 d5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.