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Propargyl-PEG2-NHBoc
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Propargyl-PEG2-NHBoc图片
CAS NO:869310-84-9
包装与价格:
包装价格(元)
100mg电议
250mg电议

产品介绍
Propargyl-PEG2-NHBoc 是一种可降解 (cleavable) 的 ADC linker,用于抗体偶联药物 (ADCs) 的合成。Propargyl-PEG2-NHBoc 是一种 PROTAC linker,属于 PEG 类。Propargyl-PEG2-NHBoc 可用于合成一系列 PROTAC 分子。
Cas No.869310-84-9
分子式C12H21NO4
分子量243.3
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Propargyl-PEG2-NHBoc is a cleavableADC linkerused in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-NHBoc is a PEG-basedPROTAC linkercan be used in the synthesis of PROTACs[1].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.